The Cell and Molecular Biology group, Department of Biology, Queen's University (Kingston, Canada) is focused on eukaryotic organisms with an interest in developmental problems. The yeast model systems offer powerful molecular genetic methodology and genomics tools to study fundamental cellular functions such as signal transduction and cell cycle regulation. What are the molecules that regulate the behavior of cells as they change their shape, position and adhesiveness to generate their three-dimensional form during morphogenesis? The answer to this question will certainly add to our understanding of the role of cell adhesion and cell signaling during tissue inflammation and metastasis.